منابع مشابه
Pharmacogenetic and Tumour Drugs
One of the main goals to improve chemotherapy in cancer patients is to increase the safety while not reducing the efficacy of therapy. Cancer chemotherapy is mainly empirical with the majority of cytotoxic agents given at a fixed dosage based on either body surface area or weight. These compounds have a narrow therapeutic index, and there is no simple index for monitoring pharmacological effect...
متن کاملTranscriptional responses of Bacillus subtillis and thuringiensis to antibiotics and anti-tumour drugs.
DNA supercoiling is a major regulator of transcription in all organisms. This process is regulated by type I and type II DNA topoisomerases that are targets for microbial antibiotics and/or anti-tumour drugs. Despite extensive studies in this field, no information is available on the response of Bacillus (B) species to eukaryotic DNA topoisomerase inhibitors. Here we found that B. thuringiensis...
متن کاملNew anti-epileptic drugs.
Epilepsy represents the most common serious neurological disorder, with a prevalence of 0.4 - 1%. Approximately 30% of patients are resistant to currently available drugs. New anti-epileptic drugs are needed to treat refractory epilepsy, improve upon current therapies, improve the prognosis of epilepsy and to prevent the epileptogenic process. Designing compounds with specific physiological tar...
متن کاملAnti-anginal drugs
This review of studies on anti-anginal agents and their use in the anginal syndrome shows nitroglycerin to be unsurpassed in clinical effectiveness. It has a rapid onset of action. Its duration of action is relatively short but the need for a more prolonged effect has not been demonstrated. Most anginal attacks subside upon resting and the requirement for relief is immediate rather than prolong...
متن کاملNonsteroidal anti-inflammatory drugs.
Non-steroidal anti-inflammatory drugs (NSAIDs) are usually defined as those agents that inhibit one or more reactions involved in the production of prostaglandins and thromboxanes, important mediators of the inflammatory process in many organs and tissues. They find use in horses in the supportive treatment of a variety of systemic states and painful musculoskeletal or soft tissue conditions. T...
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ژورنال
عنوان ژورنال: British Journal of Cancer
سال: 1975
ISSN: 0007-0920,1532-1827
DOI: 10.1038/bjc.1975.309